Carbohydrates are considered as biomolecules playing numerous biological roles and can act as receptors part for several microbial pathogens as well as a barrier to microbial infection. Here we synthesize five novel methyl α-D-mannopyranoside (1) analogues following regioselective acylation, where, methyl 6-O-propionyl-α-D-mannopyranoside was converted into 2,3,4-tri-O-propionyl analogues with excellent percentage of yields. Structural configurations of the synthesized methyl α-D-mannopyranoside analogues were confirmed by spectroscopic, physicochemical, and elemental study. Prediction of activity spectra for substances (PASS) and in vitro antimicrobial experiment of the methyl α-D-mannopyranoside analogues against seven human and plant pathogenic microorganisms transpired solid antibacterial and antifungal activities are studied. Most of the compounds exhibited salient antibacterial …
https://www.sciencedirect.com/science/article/abs/pii/S002228602301092X
